Boston biotech?s big challenge: a new drug for schizophrenia

Karuna Pharmaceuticals is working on what would be the first dramatically new treatment for the disease in decades.

Mary McAleese, the former president of Ireland, said, ?I still believe the world needs the hope of God and the church as a conduit,?

Globe photo/file

Kevin Cullen

Mary McAleese knows her place

Ireland?s former leader has repeatedly drawn the ire of the church. ?I?m sorry for Catholic Ireland to have you as president,? the late Cardinal Law once told her.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/03/BostonGlobe.com/Metro/Images/daviscamb4met.jpg Cambridge man?s killing in park appears random, DA says

There is no evidence to suggest Paul Wilson, 60, was targeted in last week?s attack, Marian Ryan told nearby residents Thursday.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2018/11/30/BostonGlobe.com/Metro/Images/ryanencore3met.jpg The Everett casino and where it stands

Don?t have time to read every Greater Boston casino story? Just catch up with this one. We?ve anticipated your questions and provided some bite-sized answers.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/Metro/Images/allston.png Mass. Pike in Allston, Soldiers Field Road set for a major overhaul

The $1.1 billion project promises to radically reshape the western face of the city and will certainly disrupt travel for years.

President Trump spoke to the media as he left the White House Thursday for a trip to the border in Texas as the government shutdown continues.

Trump claims he never said Mexico would cut a check for the wall. Let?s go to the tape

On his way to visit the border, President Trump tried to clarify his past promise that Mexico would pay for the wall: ?I never meant they?re going to write out a check.?

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2018/12/11/BostonGlobe.com/Metro/Images/1210-BHR-NWS-L-121018courtfn03[1]-23797.jpg Driver charged in deaths of 5-year-old, infant apologizes: ?I feel horrible?

A 42-year-old Boston pipefitter who allegedly crashed her SUV last month into five pedestrians in Revere, killing a 5-year-old girl and her 2-month-old sister, said she?s ?heartbroken.?

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/Metro/Images/01_1943%20Bronze%20Lincoln%20Cent.jpg Rare penny found in Pittsfield in 1940s sells for $204k at auction

Don Lutes Jr., who died in September, found the bronze penny in his lunch money when he was in high school.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/11/BostonGlobe.com/Metro/Images/kreiter_citycouncilheadshots1_met.jpg Boston city councilor McCarthy says he won?t run again

Hyde Park resident McCarthy, who represents District 5, says he will serve the remainder of his term.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/11/BostonGlobe.com/Metro/Images/swensen1811910potquestions0020.jpg Cannabis panel seeks authority to scrutinize shops? pacts with towns

State law caps the value of payments to municipalities, which are intended to offset the costs of hosting a marijuana business, at 3 percent of each firm?s annual revenue.

?SMILF? showrunner and star Frankie Shaw, seen during Season 2, said she?ll make changes.

Mark Schafer/Showtime

After claims of problems on ?SMILF? set, Frankie Shaw says she?ll ?do better?

A Hollywood Reporter story last month said the show, set in South Boston, was ?a production plagued by allegations of abusive behavior and violations of industry rules.?

Boston-01/10/19 The Boston Bruins vs the Washington Capitals- Bruins Zdeno Chara gets checked over the boards and into the Capitals bench in the 1st period by Capitals Alex Ovechkin. Photo by John Tlumacki/Globe Staff(sports)

capitals 4, bruins 2

Bruins come up short against Capitals

Alex Ovechkin scored his 31st and 32nd goals of the season for Washington.

Miami Heat forward James Johnson, top, goes to the basket against Boston Celtics guard Kyrie Irving (11) during the first half of an NBA basketball game, Thursday, Jan. 10, 2019, in Miami. (AP Photo/Joel Auerbach)

HEAT 115, CELTICS 99

Celtics fall short in Miami

Boston?s four-game winning streak came to an end.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/11/BostonGlobe.com/Lifestyle/Images/200_tim_tebow.jpg Tim Tebow gets engaged to former Miss Universe

The one-time Heisman Trophy winner plans to marry Demi-Leigh Nel-Peters, a South Africa native and the 2017 Miss Universe.

Names

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/Arts/Images/5969279f2d3f4774b72c2c86932012f0-5969279f2d3f4774b72c2c86932012f0-0.jpg Peter Farrelly apologizes for exposing genitals to Cameron Diaz, others

?I did this decades ago and I thought I was being funny and the truth is I?m embarrassed and it makes me cringe now,? he said.

SCOT LEHIGH

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/EditorialOpinion/Images/11LEHIGH.jpg A bad first bid on new education funding

The next infusion of state educational dollars shouldn?t be no-strings-attached funds.

EDITORIAL

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/Ideas/Images/comped.jpg Congressional Dems ready their subpoena guns

The Democrats need to focus Trump probes on what matters: corrupt acts, violations of the rule of law, and policies with real life and death impact.

TOPSHOT - US Representative Alexandria Ocasio-Cortez, Democrat of New York, leaves a photo opportunity with the female Democratic members of the 116th US House of Representatives outside the US Capitol in Washington, DC, January 4, 2019. (Photo by SAUL LOEB / AFP)SAUL LOEB/AFP/Getty Images

SAUL LOEB /AFP/Getty Images

Opinion | Margery Eagan

?Extremists? like Warren and Ocasio-Cortez are actually closer to what most Americans want

Elizabeth Warren and Alexandria Ocasio-Cortez are actually closer to the mainstream of what Americans want from their government.

Names

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/Arts/Images/20181222-1847.jpg See photos from Meghan Trainor?s wedding

?It?s the beginning of an awesome, whole new life,? the Nantucket native told People.

DAN SHAUGHNESSY

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/Sports/Images/shaughnessy1-25342.jpg Patriots-Chargers playoff history is brief but memorable

It all began in 1964 with a tipped-off and steroid-fueled Chargers team winning the AFL Championship.

L'Espalier chef/owner Frank McClelland in the kitchen of the Back Bay restaurant on Dec. 26. The renowned eatery closed days later.

Here?s a look at the Boston-area restaurants that have closed recently (or will close soon)

Several venerable Boston-area restaurants have announced they would close their doors in the last several weeks.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/Arts/Images/13booksStackWeb2.jpg Books we can?t wait to read in 2019

It?s a big year for fiction but there will be plenty for nonfiction fans, too.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/04/BostonGlobe.com/Metro/Images/tlumackiagefriendly088.jpg Landing jobs, finding care: New site hopes to help boomers navigate post-retirement life

Tim Driver sees navigating later years ? landing jobs, deciding where to retire, finding elder care ? as an untapped market for online ratings and recommendations.

Special reports

Boston, MA - 1/16/1919: Looking across North End Park on Jan. 16, 1919, the day after a giant tank at the Purity Distilling Co. on Commercial Street collapsed, sending a wave of an estimated 2.3 million gallons of molasses through the streets of Boston. The great molasses tank was located in the center of this picture. Sections of the metal may be seen at the extreme left and right in the picture. Twenty-one people perished, including two 10-year-olds, Pasquale Iantosca and Maria Distasio, who were collecting firewood near the molasses tank while home from school for lunch. (Boston Globe Archive/) --- BGPA Reference: 150115_MJ_001

Boston Globe Archive

Globe Magazine

The day Boston was swamped by a deadly wave of molasses

One hundred years ago this month an enormous steel tank ruptured, sending a torrent of brown syrup on a deadly path through the North End.

The Big Picture

Ross D. Franklin/Associated Press

The Big Picture

The year 2018 in pictures: Part II

Here are the photos from July to December that summed up the year.

Podcasts

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2018/12/18/BostonGlobe.com/Metro/Images/gladiator%20pic5.jpg Aaron Hernandez and Football Inc.

The story of a profoundly troubled young man and the ugly underside of America?s most popular sport.

Newsletters

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2018/12/17/BostonGlobe.com/Sports/Images/basketball-25069-U831060564319fkD--90x90@BostonGlobe.com.jpg Court Sense

Follow the Celtics? quest for a title and other NBA news both on and off the court. Sign up here.

STAT

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2019/01/10/BostonGlobe.com/National/Images/GettyImages-918845942-1024x576.jpg With search for Alzheimer?s drugs failing, tech firms offer solutions

Technology companies are looking to help patients and caregivers cope with the disease.

Love Letters: The Podcast

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2018/08/29/BostonGlobe.com/Lifestyle/Images/200_love_letters_bonus.jpg Love Letters: Until next year, my sweetheart

In a special bonus episode, Meredith Goldstein explores what happens to summer romance when the summer ends, and ?Wet Hot American Summer? creator David Wain shares a girl-crazy memory from his own camp days.

Listen:   Apple Podcasts   |   Stitcher   |   RadioPublic