The new cost of hope

The families of thousands of children who want Spinraza, a newly approved drug for spinal muscular atrophy, have faced hurdles ranging from slow ramp-ups at hospitals to resistance by health insurers spooked by the $750,000 list price for the first year.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/10/17/BostonGlobe.com/Metro/Images/turner101717BIZXXspinrazaday2main44.jpg At a UMass lab, a eureka moment

This creation story began in a lab at the University of Massachusetts Medical School in Worcester.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/20/BostonGlobe.com/Business/Images/11-20-2017_sickelcell_02.jpg No miracle cure for rising drug costs

Conflicting interests in the health care industry make it difficult to reach a consensus on what to do.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/16/BostonGlobe.com/Business/Images/mehmud_4.jpg ?Five mils of this stuff is $125,000?

A neurologist and his patient coordinator scramble to launch a Spinraza program at Johns Hopkins where 80 patients remain on a waiting list.

More than 200 people were on hand for the funeral of Natalino Gomes this month.

Dina Rudick/Globe Staff

Dreams of peace, family felled by gunfire

Despite efforts to get him out of Bowdoin-Geneva, Natalino Gomes could not leave his neighborhood.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Metro/Images/858685210.jpg Uptick in HIV among injecting drug users raises fears of a resurgent epidemic

Health officials are worried that young people, unschooled in safe injection practices, could spark an outbreak.

Patriots at Steelers | 4:25 p.m. (CBS)

TARA SULLIVAN

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/04/BostonGlobe.com/Sports/Images/tara_sullivan_20171204.jpg An ode to Brady vs. Roethlisberger

This Patriots-Steelers matchup is a reason to stop and appreciate how long and how well each has played QB for his franchise.

Critical moment



Boston. Racism. Image. Reality.

Audience members at the city?s dialogue on race listened to a speaker.

Spotlight series a topic in city?s second major dialogue on race

Mayor Marty Walsh fielded questions on racial disparity, the Globe?s series on racism, and school start times, among other topics.

Part seven: Solutions

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Metro/Images/Clipboard-11642.jpg A better Boston? The choice is ours

There have been years of halting progress, steps forward and back. It is high time to break that pattern.

President Trump walked towards Marine One as he departed from the South Lawn of the White House on Saturday.

Susan Walsh/Associated Press

analysis

Trump?s greatest mission: erasing Obama?s legacy

Some attempts have failed, but the intensity of the president?s anti-Obama movement has never ebbed.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Metro/Images/25437519_10215342327734904_659867753_n.jpg Mom angry after teen suspended for taking Scout knife to school

Ife Oshun says Milton?s middle school was ?overstepping its boundaries. . . . He didn?t do anything wrong.?

Bostonians of the Year

The Sleuths

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/11/BostonGlobe.com/Magazine/Images/teens1217boty.jpg Teen activists uncover forgotten TD Garden fund-raiser promise

Once upon a time, the Garden?s owners promised to host three annual fund-raisers for the community. Everyone forgot about it until these six teens started digging.

CELTICS 102, GRIZZLIES 93

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Sports/Images/64a2903671ec4036aeee21bbaec177df-64a2903671ec4036aeee21bbaec177df-0.jpg Celtics rebound by repelling Grizzlies

Boston reestablished control in the fourth quarter after squandering a big early lead.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Metro/Images/StormTotalSnowWeb1.jpg Snow will stick around until Monday morning

An inch of snow could fall Sunday overnight into Monday, messing up the roads for the first rush hour of the week.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Metro/Images/unnamed%20(7).jpg Woman rescued from icy pond in Groveland

The woman crashed a car into Johnsons Pond Saturday and was pulled from the water by police, officials said.

Starts & Stops

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/15/BostonGlobe.com/Metro/Images/16baker01.jpg T celebrates progress ? even if passengers don?t feel it

Can the T really claim to be turning things around if riders still find the system unreliable?

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/06/BostonGlobe.com/Regional/Images/davis_baby1_nowk.jpg Baby in workplace welcomed with open arms

Caitlyn Aguiar and her 3-month-old son are the first to participate in a Lowell credit union?s Infant at Work program.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Foreign/Images/Rex_Suicide_bomb_attack_at_a_Church_9295336A.jpg 5 dead after suicide bombers attack church in Pakistan

Hundreds of worshipers were attending services at a church in Quetta ahead of Christmas.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/WebGraphics/Sports/BostonGlobe.com/2016/01/20moresports/seasonticket_90.jpg The Season Ticket podcast

Guest host Chad Finn chats with NFL analyst and former Pittsburgh Steelers head coach Bill Cowher.

Follow:   iTunes   |   Stitcher   |   RSS

 

Opinion & Ideas

Ideas | Sharon Begley

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/14/BostonGlobe.com/Ideas/Images/AP_132860394523.jpg Does mental illness show up in tweets?

The flaws of in-person exams are no surprise to experts.

Newsletters

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/05/BostonGlobe.com/EditorialOpinion/Images/MichaelCohenNewsletterHP-3632.jpg Truth and Consequences

Opinion columnist Michael Cohen takes a candid and no-holds-barred look at the current political moment. Sign up now.

Special reports

Magazine | A nonfiction novella

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/01/BostonGlobe.com/Magazine/Images/muck1105altimage-2940[1].jpg He put BSO on the map ? then landed in a world of trouble

One hundred years ago, one of the world?s top conductors was ensnared in a scandal involving patriotism and sex. It almost toppled Boston?s famed orchestra.

Breaking News Alerts

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/10/10/BostonGlobe.com/Lifestyle/Images/DKu5zGDUEAI5bSf.jpg Sign up for breaking news alerts from the Globe

Get the latest news ? from weather to Trump to local happenings ? delivered via Facebook messenger.

Confidential tips

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/05/22/BostonGlobe.com/Business/Images/spotlight.jpg Have an investigative news tip?

Do you know about wrongdoing that needs to be exposed? Call the Globe Spotlight team: 617-929-7483 or [email protected].

STAT

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/15/BostonGlobe.com/National/Images/metoo%20biomedical%20science.jpg In wake of #MeToo, a new spotlight on harassment in biomedical science

Dr. Reshma Jagsi published a survey last year on harassment in the lab, and has found her research has gotten a second life.