Death toll from opioid abuse still climbing in Mass.

The toll is rising despite months of intensifying efforts to combat the substance abuse crisis.

US Vice President Joe Biden (C), flanked by US President Barack Obama (L) and his wife Jill Biden (R), speaks in the Rose Garden at the White House on October 21, 2015, in Washington, DC. Biden announced that he is not running for president. AFP PHOTO / JIM WATSONJIM WATSON/AFP/Getty Images

Jim Watson/AFP/Getty Images

Biden?s decision ends speculation about his plans

Vice President Joe Biden said he would not seek the presidency because he did not have time to put together a successful bid.

Stat

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/21/BostonGlobe.com/Metro/Images/04987416[1].jpg Joe Biden calls for ?moonshot? to cure cancer

Even as he surrendered his presidential ambitions, the vice president dedicated himself to the fight against the disease.

Rep. Paul Ryan, R-Wis., speaks to reporters on Capitol Hill in Washington, Wednesday, Oct. 21, 2015, following meetings with House Republican leaders and the Freedom Caucus members. Ryan seeking unity in a place it's rarely found, is telling House Republicans he will serve as their speaker only if they embrace him by week's end as their consensus candidate. (AP Photo/Manuel Balce Ceneta)

Manuel Balce Ceneta/Associated Press

Conservatives will support Paul Ryan for speaker

The decision by the House Freedom Caucus all but guarantees that Ryan will get the job.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/01/31/BostonGlobe.com/Regional/Images/30wewaltham2-1492.jpg Waltham police, firefighters unions vote no-confidence in mayor

A dispute between Waltham?s mayor and the city?s public safety unions comes amid an election battle and contract negotiations.

Healey calls on FCC to reform phone services for inmates

Attorney General Maura Healey said costly phone services make it difficult for inmates to maintain contact with their families.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/21/BostonGlobe.com/Metro/Images/natucketsexualassaultsuspect1021aA.jpg Nantucket man charged in 2008, 2014 rapes

David Matterson, 35, was ordered held without bail on charges that he raped two women six years apart on the island.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/21/BostonGlobe.com/Business/Images/492972834.jpg Mass. Legislature, gambling panel to weigh in on fantasy sports

House Speaker Robert DeLeo said lawmakers are likely to take up regulation of DraftKings and other companies in the industry.

NFL teams may cut ties to fantasy sites amid inquiries

Teams may cut ties to fantasy sports if states evaluating their legality determine the business violates gambling laws.

Watertown, MA: 10-21-15: Watertown's field hockey team, including (l-r, foreground) captain Ally McCall, captain Michaela Antonellis, and Kourtney Kennedy celebrate their win over Melrose at Victory Field in Watertown, Mass. October 21, 2015. The game was Watertown's 154th without a loss, a national record. Photo/John Blanding, Boston Globe staff story/, Sports ( 22watertown) )

John Blanding/Globe Staff

Watertown 6, Melrose 0

Watertown field hockey team sets national record

Watertown ran its unbeaten streak to 154 games with a 6-0 victory over Melrose.

(FILES) This September 17, 2015 file photo shows boat docks sitting empty on dry land, as Folsom Lake reservoir near Sacramento stands at only 18 percent capacity, as the severe drought continues in California. The first nine months of this year have been record-breaking for heat worldwide, in another sign that dangerous global warming continues to mount, US government scientists said October 21, 2015. Last month marked the

This year is on track to be hottest on record

Global temperatures are running far above last year?s record-setting level, all but guaranteeing that 2015 will set a new mark.

BERLIN, GERMANY - OCTOBER 21: Israeli Prime Minister Benjamin Netanyahu speaks together with German Chancellor Angela Merkel arrive to speak to the media at the Chancellery on October 21, 2015 in Berlin, Germany. Netanyahu is in Berlin following the cancellation of German-Israeli government talks last week due to the security situation in Israel. (Photo by Carsten Koall/Getty Images)

Netanyahu?s comments about Holocaust elicit criticism

Israeli Prime Minister Benjamin Netanyahu was denounced for saying a Palestinian inspired Hitler to embark on the Holocaust.

National Geographic Channels

On Sunday night, it?s brain surgery on live television

The National Geographic Channel plans to broadcast the surgery, but experts say such programming can be risky and exploitative.

10/21/15: Boston, MA: The Bruins Patrice Bergeron puts the puck past Flyerrs goalie Michael Neuvirth to tie the score at 2-2 in the first period. The Boston Bruins hosted the Philadelphia Flyers in a regular season NHL hockey game at the TD Garden. (Globe Staff Photo/Jim Davis) section:sports topic:Bruins-Flyers (1)

FLYERS 5, BRUINS 4 | OT

Bruins can?t hold off Flyers at TD Garden

The Bruins allowed two goals in the third period and then lost in overtime to remain winless at home so far this season.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/21/BostonGlobe.com/Magazine/Images/pose150-1964.jpg Changing lives with a simple pose

Harvard Business School professor Amy Cuddy on power posing, confidence building, and the TED Talk that changed her life.

Lechmere station in Cambridge.

Green Line extension likely to be pushed back again

The move comes as MBTA officials look for ways to drive down the costs and find new revenue to pay for the project.

From left: Matt Czuchry as Logan, Alexis Bledel as Rory Gilmore, Lauren Graham as Lorelai Gilmore, and Scott Patterson as Luke Danes in a season 6 episode of ?Gilmore Girls.?

Matthew Gilbert

We want more ?Gilmore Girls? and ?Twin Peaks.? Should we get them?

Just because audiences may want more isn?t necessarily a reason to give it to them, is it?

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/21/BostonGlobe.com/Business/Images/wiggs_biogen_horizontal.jpg Biogen to cut 880 jobs, 400 of them in Mass.

The state?s most valuable publicly traded company will also terminate a number of its drug research programs this year.

The Big Picture

Protesters opening their umbrellas, symbols of the pro-democracy movement, in 2014.

Reuters

The Umbrella Movement, one year later

A year after Hong Kong riot police fired tear gas at pro-democracy protesters, a Reuters photographer revisited the scenes.

BetaBoston

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/21/BostonGlobe.com/Business/Images/Was8972392.jpg Michael Dell buying a home in Boston, report says

The company that bears Dell?s name is buying EMC, the last of the tech titans that once dotted Boston?s suburbs.

Crux

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/21/BostonGlobe.com/Foreign/Images/2015-10-21T120859Z_966186651_GF20000026188_RTRMADP_3_POPE-VATICAN[1]-982--90x90.jpg Vatican denies report that Pope Francis has brain tumor

The Vatican said the pope is in good health and that his head is ??absolutely perfect.??