Study stirs hope on aging disease
Steve Nighbor of Wisconsin helped his daughter Megan, 12, who has been diagnosed with progeria, with homework.

Scott Mundro for The Boston Globe

A Children’s Hospital drug trial is offering hope that it is possible to affect the course of a rare, fatal disease that causes children to age prematurely and die before reaching adulthood.

Kate Middleton, Prince William, and Prince Harry attended the men's team sprint track cycling event at the London 2012 Olympic games.

Joanna Weiss

Royalty and the paradox of publicity

The scandal over nude photos of Kate Middleton could be the best thing to happen to the royal family in ages because it makes them look human, and therefore relevant.

Wednesday Preview | Movie Review

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2012/09/21/BostonGlobe.com/Arts/Images/Donald_Trump_on_Dunes.jpg ‘You’ve Been Trumped’ puts the Donald in the rough

Does America have a more laughably contemptible public figure than Donald Trump?

Opinion | Paul Mcmorrow

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2012/09/25/BostonGlobe.com/EditorialOpinion/Images/greenhouse_kensington2_business.jpg Boston’s housing boom could have economic windfall

The current Boston-area apartment-building explosion should be viewed as a long-term economic development strategy, because those housing units will attract skilled, educated workers.

Latest news

 

UMass medical center to cut 140 jobs

UMass Memorial Health Care said it will pare another 140 full-time jobs at its flagship hospital in Worcester, on top of 150 positions eliminated since February.

Elizabeth Warren ‘appalled’ by actions of GOP staffers

In response to a video that appears to show Republicans mocking her Native American ancestry claims, Warren said there would be “serious consequences” if her staffers did something similar.

Chicago Cubs president Theo Epstein talked to reporters before a game last month.

Democrat-leaning Theo Epstein works for major GOP backer

Epstein, who was among fellow Democratic backers with the Red Sox, now works for a major funder of a conservative super PAC with the Cubs.

Chemist in drug lab scandal apparently lied on resume

Former state chemist Annie Dookhan does not have a master’s degree in chemistry from UMass Boston as she claims, school officials said.

President Obama addressed the UN General Assembly on Tuesday.

Obama warns Iran on nuclear program

President Obama told the UN patience with Iran is wearing thin and warned that “time is not unlimited.”

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From The Archives | Photos

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2012/09/18/BostonGlobe.com/Enterprise/Advance/Images/mag24hur1A1-731.jpg The Great Hurricane of 1938

The record-breaking storm that hit New England on Sept. 21, 1938 hit hard, killing approximately 600 people in the area.

Globe exclusives

Our Revival, wearing a fly mask, grazes at a Kentucky retirement home for thoroughbreds after she was rescued from kill buyers.

Suffolk trainer helped save mare from slaughterhouse
A white “ghost bike” has been placed along Morrissey Boulevard in Dorchester near where a bicyclist, Doan Bui, was struck and killed Sept. 14 by an alleged drunken driver.

‘Ghost bikes’ are haunting reminders of dead cyclists
Senate candidate Elizabeth Warren spoke to reporters after debating incumbent Scott Brown last week. Brown has criticized Warren for her role in an asbestos case.

Warren assisted mining company
Officials seemed to indicate opposite reactions to the game-ending play in the Seahawks’ win over the Packers. At left, the official appears to indicate an interception, while the official on the right called a touchdown.

Timeline

How the NFL’s replacement refs have erred
Mindy Kaling plays an ob/gyn, which was her mother’s real-life profession.

Mindy Kaling’s mother inspired new TV ‘Project’
David Byrne & St. Vincent on NBC’s “Late Night with Jimmy Fallon.”

music review

David Byrne and St. Vincent a dynamic duo at Orpheum
Gabriel, shown here in a previous concert, was in Boston Monday.

MUSIC REVIEW

Peter Gabriel replays ‘So’ at TD Garden
EF First Education’s new $125 million, 300,000-square-foot headquarters will be situated at the foot of the Zakim Bridge. Construction is to begin Tuesday and be completed by spring of 2014.

New NorthPoint project making a big splash
An audience listened during a forum by doctors and attorneys about hepatitis C in Exeter, N.H., in August.

Ethics of hepatitis C drug pitch questioned
Patriots coach Bill Belichick is seen talking with a referee after Sunday’s game

editorial

Belichick deserves a fine but not a suspension
From left: Michael Chiklis, Kai Lennox, James Russo, Dennis Quaid, and Jason O’Mara in “Vegas,” a new drama from CBS.

Television Review

Ace actors can’t save ‘Vegas’

Chandler Delinks had to get through sand and an accidentally catapulting competitor.

G Cover

Racing goes off-road in cyclo-cross

Sports

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Officials ruled the Seahawks had scored a touchdown after they sorted out this scrum at the end of Monday’s game.

NFL upholds Seahawks’ disputed win

The league said that while the game result is final, officials did miss a key penalty that would have given the game to the Packers. Also, talks with locked-out officials have resumed.

Metro

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Attendees at a meeting on school assignments looked over various plans at the Lilla Frederick Pilot Middle School.

Plans upend Boston school assignments

Two of the five proposals would bring back the closest thing Boston has had to neighborhood schools since before the days of desegregation.

Columnists

The Patriots’ Bill Belichick (above) and the Ravens’ John Harbaugh spent a lot of time Sunday appealing to the refs.

Christopher L. Gasper

NFL’s replacement refs a complete joke

farah stockman

A plea for a new party: Keeping It Real
Kate Middleton, Prince William, and Prince Harry attended the men's team sprint track cycling event at the London 2012 Olympic games.

Joanna Weiss

Royalty and the paradox of publicity

Boston Capital

Stock and bond markets posting big gains
Work continues on the third set of locks during the Panama Canal Expansion project Wednesday.

Juliette Kayyem

Panama’s magic number
The free UberSense app lets coaches mark up video shot on an iPhone or iPad.

Innovation Economy

UberSense offers video sports coaching app

Adrian Walker

Fresh outlook at Fresh Pond
As he often was on Sunday night, Patriots’ Devin McCourty was a step behind as Ravens’ Torrey Smith snares a TD pass.

Christopher L. Gasper

Patriots defense, running game still struggling
Bill Belichick screams at official Rodney Russell after a first-quarter call went against the Patriots.

Dan Shaughnessy

Replacement refs a nightmare in Patriots loss
Pamela Brousseau has a cup of coffee at Women’s Lunch Place Thursday.

Joanna Weiss

For vulnerable women, an oasis on which to depend

joan vennochi

A dizzy ride on the Romney-coaster
President Jimmy Carter speaks in the East Room of the White House in 1978.

opinion | Jeff Jacoby

The ghosts of Jimmy Carter

Business

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A Staples office supply store in Miami.

Staples to close stores in turnaround effort

The Framingham-based office supply chain said it will close 30 stores in North America and downsize or relocate 30 others.

Politics

Political Notebook

Mitt Romney spoke at Pueblo Weisbrod Aircraft Museum in Pueblo, Colo., Monday.

Romney raps Obama on ‘bumps in the road’ remark

Mitt Romney is seeking to exploit what his campaign sees as a gaffe from the president’s recent “60 Minutes” interview.

Nation & World

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Government forces patrolled in Aleppo. Activists said 48 civilians and 22 regime soldiers died in fierce fighting Monday.

UN envoy says Assad remains steadfast

Syria’s peace envoy gave a bleak assessment of the stalemated war, telling diplomats that there was no immediate prospect for a breakthrough.

Arts

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Book Review

President Lyndon B. Johnson shakes hands with Martin Luther King Jr. at the signing of the Civil Rights Act of 1964,

‘All In the Family’ by Robert O. Self

Self explores how feminists, gay-rights activists, and anti-war protesters fostered a greater sense of inclusion but also inspired a fervent backlash.

Lifestyle

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G Force

Photographer poet follows migrant workers at Suffolk Downs

Melissa Shook taught photography at MIT and UMass Boston. Her subjects have included homelessness, aging, and, now, the all-but-invisible world behind Suffolk Downs.

“It’s inappropriate . . . to approach people about a research study that hasn’t been approved and to say the potential benefits outweigh the risks.”

Dr. Michael Grodin,  of BU’s public health school

Magazine

The cover for the September 23 2012 issue

9 hot trends in kitchen design
The cover for the September 16 2012 issue

The self-promoting, fan-financed, go-it-alone star
The cover for the September 9 2012 issue

Things to do in the Berkshires
The cover for the August 26 2012 issue

Did Beatrice Munyenyezi lie to get into this country?

Opinion

“We are all celebrities of a sort now, with a new understanding of what life in public means.”

Joanna Weiss 

Ideas

“Changing a culture requires finesse, subtlety, and patience. It also requires a certain suspension of optimism about human nature.”

Leon Neyfakh on the art of crowdshifting