Vertex reports strong findings from cystic fibrosis drug trials

A combination treatment dramatically improved lung function, lifting hopes for a medicine that could treat 90 percent of CF patients.

WASHINGTON, DC - JULY 17: (AFP OUT) U.S. President Donald Trump pauses while participating in a Made in America event with companies from 50 states featuring their products in the Blue Room of the White House July 17, 2017 in Washington, DC. American manufacturers representing each of the 50 states participated in the showcase, including Bully Tools, Cheerwine, Stetson, Simms and RMA Armament, Charles Machine Works, Honckley Yachts, Altec Inc., Caterpiller, Pierce Manufacturing and others. (Photo by Andrew Harrer-Pool/Getty Images)

Andrew Harrer-Pool/Getty Images

Trump says he, GOP are ?not going to own? Obamacare

President Trump made the comments as three GOP Senators said they opposed Mitch McConnell?s Plan B, which was to repeal Obamacare in full and replace it later.

Evan Horowitz | Quick Study

How the GOP?s failure to replace Obamacare threatens the rest of its agenda

Dissent from the conservative wing could surface in other Republican policies.


// The GOP doesn?t need a new health care plan. They just need to rebrand Obamacare

A modest proposal for Senate Republicans.

Ground Game

// Don?t blame Trump for the health care collapse

There is plenty of finger pointing going around for the failure of the latest health care bill. But one person who cannot be blamed is President Trump.

Person shot on Tremont Street

A person is suffering possibly life-threatening injuries after being shot on Boston?s Tremont Street, according to Boston police.

Gilford NH 7/18/17 A herd of bison running loose in Gilford NH. Photo courtsey Margaret Marceau

Herd of buffalo loose in New Hampshire

A herd of buffalo escaped from a local farm Tuesday afternoon, leading to police officers in Gilford trying to corral them.

// Driver fires into Lyft car on Southeast Expressway in Quincy

The Lyft driver was in a Toyota Prius near the Furnace Brook Parkway exit ramp.

// Globe CEO Doug Franklin steps down

Boston Globe chief executive officer Doug Franklin stepped down Tuesday, citing strategic differences with publisher John W. Henry.

Sponsored by Vermont Tourism

Your perfect weekend in Vermont has already been planned

The beauty of Montpelier, Vermont can?t be fully appreciated in a day. Instead, take a weekend to explore its bike trails, indulge in farm-to-table meals, and enjoy maple soft serve.

This content was produced by Boston Globe Media in collaboration with the advertiser. The news and editorial departments of The Boston Globe had no role in its production or display.

Len Evans of Burlington had the nicest lawn in the neighborhood until they hired Lawn Dawgs to fertilize it and kill weeds.

David L Ryan/Globe Staff

The Fine Print

He?s seeing red over his lawn?s lack of green

Hiring people to work on your home or yard is often stressful - here are a few suggestions to keep in mind when dealing with contractors.

// Baker announces shakeup as his chief of staff steps down

In an interview, Steven Kadish, who begins his day at 5 a.m. and is still working after nightfall, said he has ?run out of gas.?

// St. Paul?s top administrator defends school amid criminal investigation

Administrators offered a defense of St. Paul?s School on Monday, while acknowledging recent misconduct involving male students.

// Local officials reviewing impact of pot compromise bill

The compromise bill clearing the way for marijuana legalization in Massachusetts is drawing a muted response from city and town officials.

Bus driver Daron Banks tried out a new compressed-natural-gas bus being displayed by the MBTA in Bostonon Tuesday.

MBTA heralds arrival of 345 new buses

And 30 more new vehicles are on the way.

NFL football player Julian Edelman, of the New England Patriots, speaks at the Kids' Choice Sports Awards at UCLA's Pauley Pavilion on Thursday, July 13, 2017, in Los Angeles. (Photo by Chris Pizzello/Invision/AP)

Julian Edelman shared a letter from a professor who doubted his NFL dream

The English professor wanted to acknowledge a ?flippant comment? made in class about Edelman?s seemingly unrealistic aspirations.

?I?ve turned being an alcoholic into being a workaholic,? says Marty Walsh, who got sober more than 20 years ago.

Keith Bedford/Globe staff

Globe Magazine

Marty Walsh has a confession to make

After an early crisis of self-doubt, Boston?s 48th mayor found his own way.

// Woman who wore miniskirt in online video arrested by Saudi police

The woman wore a miniskirt and crop top in the video, exposing her legs and midriff in violation of the country?s strict dress code for women.

Marc Epstein filed a trademark suit against Christopher Kimball (above)?s business, CPK Media, a year ago in Boston federal court.

Talking Points

Cooking up legal trouble on Milk Street

A trial involving celebrity chef Christopher Kimball and Milk Street Cafe founder Marc Epstein got underway this week.

That robot that patrols the Pru? One of its brothers fell into a fountain in D.C.

Looks like the type of robot patrolling Boston?s Prudential Center isn?t as indestructible as one may think.

Renée Graham

// Is this R. Kelly?s ?Cosby moment??

It?s way past time for fans to recognize that R. Kelly is a sexual predator.

The 401(k) match is back, and it?s getting bigger

In many places, one of the first casualties of the financial crisis was the company match. Now, it seems, the match is roaring back.


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// Documenting Hate: Submit an incident you know about

If you have been a victim or witnessed a hate incident, share your information here so we can investigate.

Real Estate

Maine retreat reflects easygoing spirit of a coastal village

It?s not a summer colony for the yacht-club crowd, but a working port where every other house has boats, buoys, and stacks of lobster traps in the yard. The dominant aesthetic is whitewash and weathered, and fishing boats outnumber sailboats in the harbor.


Search This Week's Specials

A new design gives the 2018 Hyundai Sonata some fresh appeal

Sales of midsize sedans like the Hyundai Sonata have been steadily declining over the last few years. Pickup trucks and crossovers are now go-to purchases, which is something of a challenge for Hyundai. The Sonata accounts for 31 percent of all Hyundais sold in the U.S., and it?s the most well known model in their [?]