Concern mounts on opioid crisis? toll on children

Doctors, judges, and drug counselors say they are seeing more and more cases of neglect and abuse of children due to opioid-addicted parents.

Merrimack Pharmaceuticals? chief executive Bob Mulroy and head of discovery Birgit Schoeberl have a drug that aims to treat pancreatic cancer.

Jessica Rinaldi/Globe Staff

Local biotech bids to become leading cancer drug maker

Merrimack Pharmaceuticals is targeting its lead drug candidate at metastatic pancreatic cancer, a disease that has stubbornly resisted treatment.

Mother arrested in Amber Alert, baby in care of DCF

The mother was told in Pennsylvania that her baby needed medical care. She traveled to Boston, where she was arrested at Boston Children?s Hospital.

Shire?s possible blockbuster eye drug delayed by US regulators

The drug to treat dry-eye disease will take more time to get approval after regulators asked for additional testing.

Temperatures below freezing expected tonight

A freeze warning was issued for much of Eastern Massachusetts overnight until 9 a.m. Sunday.

Retired professor David Kelly on the Hampshire College campus. Photo/Amanda Schwengel

Amanda Schwengel/Hampshire College

Starts and Stops

Hampshire College changes speed limits to honor math professor

When David Kelly retired, the school changed its speed limits to 17 miles per hour, in honor of his favorite number.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/17/BostonGlobe.com/Metro/Images/1012920_669833803044266_451514381_n-8861--90x90.jpg Former Uber driver sentenced to 10 to 12 years for rape

Alejandro Done of Boston pleaded guilty to sexually assaulting a woman he had picked up when he was driving for Uber in 2014.

Israeli police checked a Palestinian man at the the Damascus Gate in Jerusalem's Old City on Saturday.

Israelis kill 4 alleged Palestinian attackers

Israelis shot dead at least four Palestinians they said had attacked them with knives on Saturday in Jerusalem and Hebron.

Vehicles were stuck on a road after being trapped by a mudslide on California Highway 58 in Mojave, Calif.

Landslides in Calif. leave highways, vehicles inundated

Heavy rain left a section of at least one highway in California waist-deep in mud, stranding hundreds of vehicles.

Jonathan Wiggs/Globe Staff

Amputee?s high heels come courtesy of bombing survivor

Hillary Cohen is set to be the first person to receive a prosthetic leg donated by a foundation established by bombing survivor Heather Abbott.

Patriots at Colts | Sunday, 8:30 p.m. | NBC

Indianapolis fans fired up for Patriots game

Colts fans seem realistic about the matchup, even though their team is struggling to score and Andrew Luck has a shoulder injury.

How do we keep museums vital in today?s world?

How do we do justice to the power of the works they house? Sebastian Smee ponders a delicate relationship.

Travis Shaw hit 13 homers in 226 at-bats this season.

NICK CAFARDO I SUNDAY BASEBALL NOTES

Who can generate power for the Red Sox?

The Red Sox were last among AL East teams in homers. Meanwhile, eight of the 10 playoff teams were in the top 12 in home runs.

Clockwise from top: the living room and its original wood-burning fireplace; the enclosed porch, which has a bead-board ceiling; the property, with the home set back far from the street; and the updated kitchen, which has granite countertops.

photos by lane turner/globe staff

home of the week

Home in Andover radiates charm of Arts and Crafts style

The details that made this style popular have been preserved, including a layout where you step from the porch directly into the living room.

Head of the Charles

Everything you need to know about rowing the Charles

From athletic ability to race strategy, here?s what it takes to be a winning crew at the Head of the Charles Regatta.

COLLEGE BOUND

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/15/BostonGlobe.com/Regional/Images/handout_bc2_met.jpg Do early birds catch the college acceptance?

Some high school seniors are better off nailing the fall grading period before they apply.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/17/BostonGlobe.com/National/Images/84ef399ecbf84e52ad2aa47eabf840a1-84ef399ecbf84e52ad2aa47eabf840a1-0.jpg Final US Airways flight completes journey, lands in Philly

The final US Airways flight has landed in Philadelphia, completing the last leg of its roundtrip journey.

STEVEN A. ROSENBERG

With Hank Finkel, Celtic Pride still stands tall

Hank Finkel?s life has always been about working hard and taking advantage of opportunities.

The Big Picture

Protesters opening their umbrellas, symbols of the pro-democracy movement, in 2014.

Reuters

The Umbrella Movement, one year later

A year after Hong Kong riot police fired tear gas at pro-democracy protesters, a Reuters photographer revisited the scenes.

BetaBoston

Innovation Economy

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/16/BostonGlobe.com/Business/Images/reminder-tease-4914--90x90.jpg Startups serve up ways to get patients to take meds

They?re part of the entrepreneurial drive to solve a problem that costs the health care system hundreds of billions of dollars.

Crux

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2015/10/16/BostonGlobe.com/Foreign/Images/africa150-970.jpg A conversation with Catholic Africa?s lion in winter

Cardinal Francis Arinze of Nigeria is unyielding in his defense of Catholic orthodoxy.

Lifestyle

obsession

Hip, hip beret!

Despite popular belief, the beret isn?t limited to Wes Anderson heroines, baguette-wielding Parisians, and the 2012 U.S. London Olympics team.